Newer Antidiabetic Drugs
نویسنده
چکیده
The current oral blood glucose lowering agents and dietary measures only partially correct the multiple metabolic defects in NIDDM with insulin resistance remaining relatively impervious to treatment Hypoglycaemia and secondary failure are common with presently available sulphonylureas and hence the need for newer blood glucose lowering drugs. In case of NIDDM, a successful new drug should correct atleast one of the major underlying metabolic disturbances. i.e. reduce insulin resistance, enhance insulin production and secretion in response to glucose, suppress exessive hepatic glucose production or improve glucose uptake and utilisation in peripheral tissues particularly, skeletal muscle. Within the last few years three new groups of drugs have been identified and they are:
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